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SUMMARY:A systematic screen for protein–lipid interactions in Saccharomy
 ces cerevisiae - Anne-Claude Gavin\, EMBL
DTSTART:20110412T151500Z
DTEND:20110412T170000Z
UID:TALK30723@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Biological function emerges from the concerted action of numer
 ous interacting biomolecules. Deciphering the molecular mechanisms behind 
 cellular processes requires the systematic charting of the multitude of in
 teractions between all cellular components. While protein–protein and pr
 otein– DNA networks have been the subject of many systematic surveys\, o
 thers critically important cellular components\, such as lipids\, have to 
 date rarely been studied in large-scale interaction screens. The importanc
 e of protein–lipid interactions is evident from the variety of protein d
 omains that have evolved to bind particular lipids and from the large list
  of disorders\, such as cancer and bipolar disorder\, arising from altered
  protein–lipid interactions. The importance of lipids in biological proc
 esses and their under-representation in current biological networks sugges
 t the need for systematic\, unbiased biochemical screens. Here\, we report
  a screen to catalog protein–lipid interactions in yeast using a lipid a
 rrays. To illustrate the data set’s biological value\, we studied furthe
 r several novel interactions with sphingolipids\, a class of conserved bio
 active lipids with an elusive mode of action. Integration of live-cell ima
 ging suggests new cellular targets for these molecules\, including several
  with pleckstrin homology (PH) domains. The dataset presented here represe
 nts an excellent resource to enhance the understanding of lipids function 
 in eukaryotic systems
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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