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SUMMARY:Non-classical means for regulating small G-proteins - Shehab Ismai
 l\, Max Planck Institute Dortmund
DTSTART:20110317T161500Z
DTEND:20110317T180000Z
UID:TALK29962@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Small G-proteins are regarded as molecular switches that swing
  from an on state (GTP bound) to an off state (GDP bound). These switches 
 are involved in regulating many cellular events as cell growth\, prolifera
 tion\, cytoskeletal remodeling\, vesicle trafficking etc. In general\, sma
 ll G proteins are regulated by two classes of proteins. Proteins that acce
 lerate the nucleotide exchange (GEFs) and hence shift the equilibrium to t
 he on-state. Proteins that accelerate the hydrolysis of bound GTP (GAPs) a
 nd hence shift the equilibrium to the off-state. In my talk I will present
  two examples where the classical GEFs and GAPs regulation interplays with
  new signals and inputs. First I will talk about the crystal structure of 
 Arf-ArfGAP complex in the transition state. This structure clarified a dec
 ade long debate of the catalytic mechanism. And lead us to discover a new 
 calcium regulation mechanism that hints to a cross talk between the Arf an
 d calcium signaling. Second I will present\, \nusing structural\, biochemi
 cal and live cell imaging data how the Arl2/3•GTP can regulate the trans
 port of farnesylated small G-proteins. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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