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SUMMARY:Patterning the Arabidopsis leaf - Sarah Robinson\, JIC
DTSTART:20110114T130000Z
DTEND:20110114T133000Z
UID:TALK28591@talks.cam.ac.uk
CONTACT:15560
DESCRIPTION:Asymmetric cell divisions provide a universal means of generat
 ing different cell fates in the development of multi-cellular organisms. H
 owever\, their role in patterning growing tissues is not well understood. 
 Asymmetric cell divisions require tight regulation of their orientation an
 d timing. The process is particularly important in plants where growth is 
 symplastic. In this system the orientation of divisions determines neighbo
 urhoods of cells\, and the timing determines their area. Little is known a
 bout how growth\, cell division and differentiation are integrated. Format
 ion of stomata within the Arabidopsis leaf epidermis provides a physically
  accessible system to study cell divisions into a developing tissue. As de
 velopment is a dynamic multi-scale process\, we tracked plant growth at th
 e tissue\, cell and protein level by using time-lapse microscopy. The data
  captured was used to produce a descriptive model of the growing and divid
 ing cells of the leaf. Descriptive rules were then replaced by mechanistic
  ones in a stepwise manner\, recapitulating in vivo behaviour. The resulti
 ng model of asymmetric cell divisions made testable predictions\, validate
 d by further experiments. As a result\, this thesis provides a plausible m
 odel of how patterning of the stomata might be achieved by asymmetric cell
  divisions and how this pattern can be integrated into the developing tiss
 ue.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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