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SUMMARY:A Global Protein Kinase and Phosphatase Interaction Network in Yea
 st - Mauro A. Castro (CR-UK Cambridge Research Institute)
DTSTART:20101122T150000Z
DTEND:20101122T163000Z
UID:TALK25397@talks.cam.ac.uk
CONTACT:Stefan Gräf
DESCRIPTION:Breitkreutz et al.\n\nScience 21 May 2010: Vol. 328 no. 5981 p
 p. 1043-1046\nhttp://www.ncbi.nlm.nih.gov/pubmed/20489023\n\nThe interacti
 ons of protein kinases and phosphatases with their regulatory subunits and
  substrates underpin cellular regulation. We identified a kinase and phosp
 hatase interaction (KPI) network of 1844 interactions in budding yeast by 
 mass spectrometric analysis of protein complexes. The KPI network containe
 d many dense local regions of interactions that suggested new functions. N
 otably\, the cell cycle phosphatase Cdc14 associated with multiple kinases
  that revealed roles for Cdc14 in mitogen-activated protein kinase signali
 ng\, the DNA damage response\, and metabolism\, whereas interactions of th
 e target of rapamycin complex 1 (TORC1) uncovered new effector kinases in 
 nitrogen and carbon metabolism. An extensive backbone of kinase-kinase int
 eractions cross-connects the proteome and may serve to coordinate diverse 
 cellular responses.
LOCATION:Room 132\, CRI
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