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SUMMARY:Pharmacology Seminar Series: Professor Ben Lehner\, Mutate everyth
 ing: mapping the energetic and allosteric landscapes of proteins at scale 
 - Professor Ben Lehner
DTSTART:20260320T130000Z
DTEND:20260320T140000Z
UID:TALK242119@talks.cam.ac.uk
CONTACT:116482
DESCRIPTION:Friday 20 March\, 13:00 - 14:00\n\nSpeaker: Professor Ben Lehn
 er\, Sanger Centre\n\nTalk Title: Mutate everything: mapping the energetic
  and allosteric landscapes of proteins at scale\n\nBiography: Ben Lehner\,
  Senior Group Leader at the Wellcome Trust Sanger Institute\, is one of th
 e most influential geneticists of his generation. He has made fundamental 
 discoveries about the biological consequences of mutations and how they in
 teract to cause disease\, particularly cancer. He provided the first genom
 e-scale map of how mutations interact in animals\, revealing the importanc
 e of non-additive interactions in pathology and the importance of chromati
 n regulators as modifiers. His work in inter-generational epigenetics show
 ed that long-lasting trans-generational epigenetic memory of environmental
  change is possible. Professor Lehner has shown that mutagenesis can deter
 mine protein structures and he has developed the first general method to i
 dentify allosteric sites in proteins\, which holds great promise for under
 standing biological regulation and drug discovery.
LOCATION:Seminar Room (Level 2)\, Dept of Pharmacology 
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