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SUMMARY:Privileged Chiral Catalysts: Selectivity and Generality in Enantio
 selective Catalysis - Prof. Eric Jacobsen - Harvard University
DTSTART:20251204T113000Z
DTEND:20251204T130000Z
UID:TALK241702@talks.cam.ac.uk
CONTACT:James Massey
DESCRIPTION:A feature possessed by many of the most powerful synthetic met
 hods is consistent performance across a wide range of substrate combinatio
 ns. In asymmetric catalysis\, the challenge of achieving such generality i
 s compounded by the challenge of needing to achieve a high level of geomet
 ric precision in the reaction mechanism. Nonetheless\, some general asymme
 tric catalytic reactions have been identified\, and we have sought to unde
 rstand the basis for that generality. Perhaps more remarkable\, privileged
  chiral catalysts—structures that have been demonstrated to induce high 
 levels of enantioselectivity across a variety of mechanistically distinct 
 reactions—have also been identified and have proven profoundly enabling 
 to the discovery of new asymmetric catalytic reactions. This lecture will 
 describe approaches to the elucidation and discovery of general catalytic 
 systems\, including the development of a specific\, new class of privilege
 d chiral catalysts: dual H-bond donors (HBDs) bearing aryl-pyrrolidino-ter
 t-leucine motifs. Detailed case studies on the mechanism of enantioinducti
 on with these catalysts highlight the cooperative features of these simple
  organic molecules that are likely responsible for the privileged nature o
 f this scaffold.
LOCATION:Dept. of Chemistry\, Wolfson Lecture Theatre
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