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SUMMARY:Poster Flash Talks Group A: Electroencephalogram alpha-spindles in
  mice reflect stochastic fluctuations of a two coupled 2–dimension netwo
 rks of excitatory-inhibitory populations - Francois David (Collège de Fra
 nce)
DTSTART:20251202T150000Z
DTEND:20251202T150500Z
UID:TALK241087@talks.cam.ac.uk
DESCRIPTION:Brain rhythms appear as transient spindle-shaped bursts with w
 axing and waning envelopes. Yet\, the general principles governing their e
 mergence remain unclear\, obscured by biophysical complexity. Here\, by re
 cording 4&ndash\;16 Hz EEG &alpha\;-spindles alongside the concurrent firi
 ng of large populations of thalamic and cortical excitatory and inhibitory
  neurons with Neuropixels electrode in anesthetized mice\, we introduce a 
 minimal modeling framework&mdash\;a two-dimensional stochastic system with
  a stable focus&mdash\;to explain how spindle amplitude and frequency vary
  with anesthesia depth. We show that &alpha\;-spindle amplitude is determi
 ned by the excitation&ndash\;inhibition balance and neuronal firing variab
 ility. Coupling two such systems with variable interaction strength genera
 tes faster or slower spindle types\, linking network interactions to mixed
 -frequency dynamics. Our results uncover a parsimonious dynamical principl
 e governing spindle generation and the control of their amplitude and freq
 uency\, bridging single-neuron activity\, network rhythms\, and anesthesia
  depth monitoring.
LOCATION:Seminar Room 1\, Newton Institute
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