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SUMMARY:LMB Seminar - Reconstructing biomolecular condensates for translat
 ion - Ruth Lehmann\, Whitehead Institute\, MIT
DTSTART:20260327T110000Z
DTEND:20260327T120000Z
UID:TALK240475@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Cells use biomolecular condensates to organize and regulate wh
 en and where proteins are made. Among these\, cytoplasmic RNA granules\, i
 ncluding stress granules\, P bodies\, neuronal RNA granules\, and germ gra
 nules\, play a key role in storing and activating mRNAs\, yet how individu
 al components drive their function has been difficult to disentangle. By r
 ebuilding germ granules from defined parts\, we found that the DEAD-box RN
 A helicase Vasa and a simple RNA-binding scaffold are sufficient to recrui
 t specific RNAs and trigger their translation. These findings reveal a min
 imal module for localized protein synthesis and show how synthetic biology
  can shed light on the principles of cellular organization.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) 
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