BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Mechanics of blastocyst morphogenesis  - Jean-Léon Maître\, Inst
 itut Curie
DTSTART:20251110T143000Z
DTEND:20251110T153000Z
UID:TALK236419@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Abstract: \n\nDuring preimplantation development\, the mammali
 an embryo forms the blastocyst consisting of a surface epithelium envelopi
 ng a fluid-filled lumen and a cluster of pluripotent stem cells. The archi
 tecture of the blastocyst is key to uterine implantation and further devel
 opment. The shaping of the blastocyst is the result of changes in the phys
 ical properties of the cells\, which generate the forces sculpting the emb
 ryo. These forces typically originate from the cytoskeleton\, adhesion mol
 ecules of the osmotic machinery. In the lab\, we use live microscopy to ob
 serve shape changes across spatiotemporal scales\, biophysical tools to ch
 aracterize the changes in physical properties of cells and tissues\, and g
 enetics to disrupt morphogenesis. This led us to discover the major contri
 bution of cell contractility throughout preimplantation morphogenesis in b
 oth mouse and human embryos as well as the physical nature of the mechanis
 ms leading to the positioning of the lumen within the embryo.
LOCATION:Online
END:VEVENT
END:VCALENDAR