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CATEGORIES:Biochemistry Seminar Series - External Speakers
SUMMARY:The SEISMIC facility for spatially resolved single
  and sub-cellular omics - Melanie Bailey - Kings C
 ollege London
DTSTART;TZID=Europe/London:20251127T150000
DTEND;TZID=Europe/London:20251127T160000
UID:TALK235570AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/235570
DESCRIPTION:The SEISMIC facility is a new BBSRC national facil
 ity that is advancing single cell and sub-cellular
  measurements.  We use capillary sampling to sampl
 e live cells or sub-cellular compartments under mi
 croscope observation\, and measure them using mass
  spectrometry.  We will also show how lipid and me
 tabolite profiles of single cancer cells respond t
 o drug\, infection and radiation treatment [1-5]. 
  We will present new work showing sub-cellular met
 allomics and proteomics. Finally\, the talk will d
 escribe a new approach to multimodal imaging using
  both keV and MeV ion beams\, providing the opport
 unity to co-localise metals with biomolecules at s
 ub-cellular spatial resolution.\n\n \n\n \n\nBio\n
 \nMelanie Bailey is Professor of Physical Sciences
  of Life at Kings College London and Professor of 
 Analytical Science at the University of Surrey.  S
 he is Director of SEISMIC\, a new BBSRC national f
 acility for spatially resolved single and sub-cell
 ular “omics” and is Principal Investigator for an 
 EPSRC funded project to bring new instrumentation 
 for multimodal imaging at the UK National Ion Beam
  Centre for correlative imaging of metals and othe
 r omics markers. She is a member of the internatio
 nal advisory board for the Ion Beam Analysis confe
 rence series\, International Nuclear Microprobe co
 nference series and the Bragg Institute. She is a 
 Trustee of the Analytical Chemistry Trust Fund and
  recently obtained a Guiness World Record as “Fast
 est Marathon Dressed as a Cell” to raise awareness
  and funding for analytical science. She is Editor
  in Chief of the Royal Society of Chemistry’s long
 est running journal “Analyst”.\n\n \n\n[1] Lewis\,
  H.-M.\, et al. (2023). "Nanocapillary sampling co
 upled to liquid chromatography mass spectrometry d
 elivers single cell drug measurement and lipid fin
 gerprints." Analyst 148(5): 1041-1049.\n\n[2] Saun
 ders\, K. D.\, et al. (2023). "Single-Cell Lipidom
 ics Using Analytical Flow LC-MS Characterizes the 
 Response to Chemotherapy in Cultured Pancreatic Ca
 ncer Cells." Analytical Chemistry 95(39): 14727-14
 735.\n\n[3] von Gerichten\, J.\, et al. (2024). "S
 ingle-Cell Untargeted Lipidomics Using Liquid Chro
 matography and Data-Dependent Acquisition after Li
 ve Cell Selection." Analytical Chemistry 96(18): 6
 922-6929.\n\n[4] Kontiza\, A.\, et al. (2024). "Si
 ngle-Cell Lipidomics: An Automated and Accessible 
 Microfluidic Workflow Validated by Capillary Sampl
 ing." Analytical Chemistry 96(44): 17594-17601.\n\
 n[5] Saunders et al (2025) \, Analytical Chemistry
  10.1021/acs.analchem.5c02010\n\n
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Te
 nnis Court Road
CONTACT:
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