BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Modelling drug resistance evolution - Trevor Graham (Institute of 
 Cancer Research (ICR))
DTSTART:20250918T111000Z
DTEND:20250918T113000Z
UID:TALK235444@talks.cam.ac.uk
DESCRIPTION:The evolutionary dynamics that lead to the emergence of drug r
 esistance in cancer\, and the molecular mechanisms that cause resistance\,
  are in general poorly characterised. Manipulation of the both the evoluti
 onary dynamics and molecular mechanisms offers potential new routes to bet
 ter treat resistant disease.&nbsp\;\nI will describe how mathematical mode
 lling of clonal lineage tracing data reveals both the dynamics of resistan
 ce evolution and resistance mechanism class (genetic selection vs phenotyp
 ic plasticity)\, without requiring any specific measurement of cell phenot
 ypes.\nWe have used this technology to establish our Evolutionary-informed
  resistance assays (EIRAs) platform\, which we hope can help accelerate th
 e development of new treatments for drug resistant disease.\nRelevant publ
 ication: https://www.nature.com/articles/s41467-025-59479-7
LOCATION:Seminar Room 1\, Newton Institute
END:VEVENT
END:VCALENDAR