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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Active Gel Theory in Practice: Decoding Dynamics o
 f Actomyosin Systems - Yuting Irene Li (Institute 
 of Science and Technology (IST Austria))
DTSTART;TZID=Europe/London:20250912T103500
DTEND;TZID=Europe/London:20250912T111500
UID:TALK233380AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/233380
DESCRIPTION:Active gel theory offers elegant\, minimal models 
 for active matter systems built from symmetry and 
 conservation principles. Yet\, biology rarely coop
 erates with our theoretical ideals. Using the acto
 myosin dynamics of the zebrafish embryo as a case 
 study\,&nbsp\;a system that undergoes partial divi
 sion in contrast to traditional complete cytokines
 is models\,&nbsp\;I will demonstrate how systemati
 c\, biologically-motivated extensions to the canon
 ical active gel models reveal the hidden complexit
 y of cytoskeletal systems. While simple isotropic 
 contractility fails to explain the observed densit
 y and velocity profiles\, incorporating nematic co
 ntractility and nematic order stabilization predic
 ts the formation of contractile actin cables and m
 echanically-uncoupled depletion zones observed exp
 erimentally. We then distill these insights from t
 he mesoscale into&nbsp\;a higher-level abstraction
  by treating the cable and cortex as coupled mecha
 nical components\, which yields remarkably accurat
 e predictions of embryo shape deformations. Overal
 l\, the&nbsp\;hierarchical modelling approach capt
 ures the essential physics of the zebrafish cleava
 ge\, illustrating an example of turning active mat
 ter theories into tractable frameworks for biology
 .&nbsp\;
LOCATION:External
CONTACT:
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