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SUMMARY:Immune-brain communication at the brain borders - Dr. Aleksandra D
 eczkowska\, Institut Pasteur
DTSTART:20250626T110000Z
DTEND:20250626T120000Z
UID:TALK232465@talks.cam.ac.uk
CONTACT:Lucy Theobald
DESCRIPTION:In contrast to other organs\, the CNS is surrounded by special
 ized barriers that limit its contact with immune cells and microbial produ
 cts in the blood. However\, such factors dynamically shape brain function 
 in homeostasis and disease. Because of this unusual anatomy\, the pathways
  of blood-brain communication are still poorly understood\, while this und
 erstanding would provide fundamental insight into brain function regulatio
 n and neurological disease mechanisms.\n\nThe choroid plexus (CP) epitheli
 um is a monolayer barrier tissue\, which on the side facing the blood can 
 sense such peripheral factors and on the side facing the brain\, produces 
 the cerebrospinal fluid (CSF)–a liquid carrying nutrients and signaling 
 molecules\, which contacts nearly all brain cells\, and ensures brain home
 ostasis. We study how the peripheral immune and microbial factors may shap
 e brain function indirectly via regulation of the CSF properties at the CP
  epithelium in brain development\, normal physiological function\, aging\,
  and disease. Our goal is to identify fundamental principles of physiologi
 cal brain regulation by the peripheral factors to pave the way for future 
 investigation of the gut-blood-CP-brain communication circuit in neurologi
 cal disease.\n\nA seminar from the Department of Clinical Neurosciences
LOCATION:Clifford Allbutt Building Lecture Theatre\, Cambridge Biomedical 
 Campus
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