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SUMMARY:Cancer Diagnostics and Therapy with DNA Aptamer Nanotechnology - P
 rof. Maxim Berezovski\, University of Ottawa\, Canada
DTSTART:20250417T110000Z
DTEND:20250417T120000Z
UID:TALK229639@talks.cam.ac.uk
CONTACT:Alexei Lapkin
DESCRIPTION:This presentation explores the innovative application of DNA a
 ptamer nanotechnology in cancer diagnostics and therapy. Cancer-specific D
 NA aptamers have been developed to address critical challenges in tumor lo
 calization\, margin assessment\, circulating tumor cell detection\, and ad
 juvant treatment. Two novel aptamer-based technologies are highlighted: Ap
 tamer-assisted Fluorescence-Guided Surgery (AptaFGS) and Aptamer-guided Ma
 gnetoDynamic cell disruption (AptaMD).\nIn AptaFGS\, a tumor-specific apta
 mer spray is formulated for glioblastoma neurosurgery. This approach elimi
 nates the need for systemic drug administration\, offering a simple\, rapi
 d procedure that enables surgeons to distinguish tumor tissue from healthy
  tissue in real-time.\nAptaMD uses aptamer-modified gold-coated magnetic n
 anoparticles exposed to an alternating magnetic field for selectively dest
 roying cancer cells. This technique achieves tumor cell disruption without
  inducing heat damage\, preserving the surrounding healthy tissue.\nThese 
 advancements demonstrate the potential of synthetic affinity ligands (apta
 mers) to improve intraoperative tumor imaging and postoperative cancer cel
 l eradication\, paving the way for more precise and effective cancer treat
 ments.\n
LOCATION:LT2\, Department of Chemical Engineering and Biotechnology\, Phil
 ippa Fawcett Drive
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