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SUMMARY:Immune-related cellular niches in the regenerating heart  - Dr Fil
 ipa Simões  Institute of Developmental and Regenerative Medicine - Univer
 sity of Oxford
DTSTART:20250227T130000Z
DTEND:20250227T140000Z
UID:TALK226972@talks.cam.ac.uk
CONTACT:Denise Hatherly
DESCRIPTION:Zebrafish have the remarkable ability to regenerate their hear
 t after injury. Macrophages are critical in this process: they clear up de
 ad cells and debris\, participate in fibrosis but also contribute to regen
 eration through interactions with their tissue microenvironment. However\,
  little is known about the precise regulation shaping macrophage identity 
 and function in response to cardiac injury. By combining single-cell and s
 patial transcriptomics\, we discovered the composition and activation stat
 es of various immune cell populations found in distinct spatial territorie
 s of the regenerating and homeostatic heart. We uncovered information abou
 t macrophage\, dendritic\, B and NK cell transcriptomes and their correspo
 ndent location within the cardiac tissue\, including the epicardium\, the 
 outflow tract\, as well as the injury-zone cardiomyocyte microenvironment.
  By reconstructing immune-related cellular niches across the regenerating 
 and the homeostatic heart\, we were able to discover the molecular signatu
 res mediating such specific cell-cell communication\, therefore contributi
 ng towards dissecting the regulatory programmes driving macrophage pro-fib
 rotic and pro-regenerative phenotypes. Further analysis is underway to und
 erstand how specific microenvironmental signaling interactions may be enha
 nced or disrupted to support tissue regeneration. Our findings reveal how 
 knowledge of cardiac niche-specific immune interactions could guide more e
 ffective pro-regenerative and anti-fibrotic therapies. 
LOCATION:VPD-HLRI\, Cambridge Biomedical Campus\, Papworth Road\, Trumping
 ton\, Cambridge CB2 0BB
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