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SUMMARY:Endurance of germinal centers in absence of Tfh cells - Dr Michell
 e Linterman\, Babraham Institute\, Cambridge
DTSTART:20241024T150000Z
DTEND:20241024T160000Z
UID:TALK221350@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:This Cambridge Immunology and Medicine Seminar will take place
  on Thursday 24 October 2024\, starting at 4:00pm\, in the Theo Chalmers L
 ecture Theatre (LT2)\, School of Clinical Medicine.\n\nSpeaker: Dr Michell
 e Linterman\, Babraham Institute\, Cambridge\n\nTitle: Endurance of germin
 al centers in absence of Tfh cells\n\nAbstract: \nT follicular helper cell
 s (Tfh) are essential for the formation of germinal center (GC) reactions\
 , and positive selection of GC B cells. Interrogating their role in an ong
 oing GC reaction has been challenging as few in vivo models manipulate Tfh
  cells in established GCs. Here\, we use an Il21 fate mapping (Il21-fm) mo
 use to genetically target Tfh cells enabling their deletion at the peak of
  the GC reaction. We show that although Tfh cells are required for driving
  ongoing GC B cell proliferation\, an established GC can withstand their t
 emporary absence. The regenerative capacity of Tfh cells results in rejuve
 nation of the GC and return of affinity maturation. This recovery suggests
  the GC has evolved to cope with environmental stresses such as co-infecti
 on-associated immune-suppression\, ensuring the generation of enduring hum
 oral immunity.\n\n\nHost: Georg Petkau\, Babraham Institute\, Cambridge\n\
 nRefreshments will be available before the seminar.
LOCATION:Theo Chalmers Lecture Theatre (LT2)\,  School of Clinical Medicin
 e\, Cambridge Biomedical Campus
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