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SUMMARY:A global map of human gene expression - Alvis Brazma (EBI)
DTSTART:20100419T150000Z
DTEND:20100419T160000Z
UID:TALK21656@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Although there is only one human genome sequence\, different g
 enes are expressed in many different cell types and tissues\, as well as i
 n different developmental stages or diseases. The structure of this 'expre
 ssion space' is still largely unknown\, as most transcriptomics experiment
 s focus on sampling small regions. We have constructed a global gene expre
 ssion map by integrating microarray data from 5\,372 human samples represe
 nting 369 different cell and tissue types\, disease states and cell lines.
  An analysis of the structure of the expression space reveals that it can 
 be described by a small number of distinct expression profile classes and 
 that the first three principal components of this space have biological in
 terpretations. The hematopoietic system\, solid tissues and incompletely d
 ifferentiated cell types are arranged on the first principal axis\; cell l
 ines\, neoplastic samples and nonneoplastic primary tissue-derived samples
  are on the second principal axis\; and nervous system is separated from t
 he rest of the samples on the third axis. We also show below that most cel
 l lines cluster together rather than with their tissues of origin. 
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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