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SUMMARY:Enhancing dimensionality of in-vitro GPCR drug discovery - Ned Wil
 ls
DTSTART:20240118T131000Z
DTEND:20240118T140000Z
UID:TALK209425@talks.cam.ac.uk
CONTACT:73285
DESCRIPTION:As the largest super-family of membrane bound receptor protein
 s\, G Protein-Coupled Receptors (GPCRs) play crucial roles not only in eve
 ryday physiology\, but many pathologies. Although over a third of FDA appr
 oved pharmaceuticals target GPCRs\, many prospective drug candidates fail 
 due to on-target but undesirable effects. Such adverse effects are likely 
 due to the pleiotropic nature of GPCR signalling pathways. Here\, the deve
 lopment of a novel biosensor platform for investigating this pleiotropy is
  outlined and the first iteration presented. The Multi-Response Element GP
 CR Sensor (MREGS) allows for the simultaneous investigation of five signal
 ling events downstream of GPCR activation using a multiplexed based assay 
 system (Sarrion-Perdigones et al.\, 2019). This system can now be applied 
 to search for more pathway specific pharmaceuticals with fewer side effect
 s. 
LOCATION:Richard King room\, Darwin College
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