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SUMMARY:Spermatogenesis: a paradigm of stem cell regulation - Ben Simons (
 University of Cambridge)
DTSTART:20231127T150000Z
DTEND:20231127T160000Z
UID:TALK208699@talks.cam.ac.uk
DESCRIPTION:To replenish cells lost through exhaustion or damage\, tissue 
 stem cells must achieve a perfect balance between renewal and differentiat
 ion. To study the factors that control such fate asymmetry\, emphasis has 
 been placed on mechanisms in which stem cell competence relies on signals 
 from a discrete anatomical niche. However\, in many tissues\, stem cell ma
 intenance takes place in an open or facultative niche\, where stem cells d
 isperse among their differentiating progenies. Using mouse spermatogenesis
  as a model\, we present evidence that stem cell density regulation relies
  on a feedback mechanism\, reminiscent of &ldquo\;quorum sensing&rdquo\; i
 n bacterial populations\, in which cells transition reversibly between sta
 tes biased for renewal and primed for differentiation. Using a modelling-b
 ased approach\, we show that this mechanism provides predictive insights i
 nto stem cell dynamics during steady-state\, as well as under perturbed an
 d transplantation conditions. We discuss the potential implications of the
 se findings for the regulation of stem cell density in other epithelial co
 ntexts\, as well as their ramifications for the elucidation of dynamic inf
 ormation from single-cell gene expression profiling data.
LOCATION:Seminar Room 2\, Newton Institute
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