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SUMMARY:Cis-regulatory control of pluripotent stem cell fates - Stefan Sch
 oenfelder (University of Cambridge)
DTSTART:20231017T120000Z
DTEND:20231017T130000Z
UID:TALK206710@talks.cam.ac.uk
DESCRIPTION:Enhancers are key gene regulatory elements in the non-coding g
 enome that coordinate spatiotemporal gene expression programmes during dev
 elopment\, often over large genomic distances. How remote enhancers relay 
 regulatory information to their target promoters has been described as one
  of the 'central mysteries of genome function and organisation'. Despite t
 heir crucial importance for normal development\, only relatively few enhan
 cers have been studied in molecular detail\, and their target genes are la
 rgely unknown. I will present methodology that we have developed to identi
 fy target genes of enhancers genome-wide at high resolution\, and I will t
 alk about the insights we have gained from applying this methodology to a 
 range of biological systems and questions. Further\, I will present our un
 published work on a novel class of non-canonical enhancers that we have re
 cently discovered in human induced pluripotent stem cells\, challenging th
 e current view that enhancers can be identified solely on the basis of a u
 nifying chromatin signature.
LOCATION:Seminar Room 2\, Newton Institute
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