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CATEGORIES:MRC LMB Seminar Series
SUMMARY:LMB Seminar: Feedback control of mitosis in the co
 ntext of the kinetochore - Andrea Musacchio\, Dire
 ctor\, Department of Mechanistic Cell Biology\, Ma
 x-Planck-Institute of Molecular Physiology
DTSTART;TZID=Europe/London:20240923T110000
DTEND;TZID=Europe/London:20240923T120000
UID:TALK206374AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/206374
DESCRIPTION:Kinetochores provide chromosomes with points of at
 tachment to spindle microtubules during cell divis
 ion\, and are therefore essential for genome inher
 itance and the propagation of life. In addition to
  binding microtubules\, kinetochores control mitot
 ic surveillance mechanisms that promote chromosome
  bi-orientation (the error correction mechanism) a
 nd prevent premature mitotic exit in presence of i
 ncomplete or incorrect microtubule attachments (sp
 indle assembly checkpoint\, SAC). Elimination of t
 he NDC80 complex\, the main microtubule receptor o
 f kinetochores\, causes a SAC deficiency\, identif
 ying this complex as a crucial regulatory focus fo
 r checkpoint function. In recent years\, there has
  been considerable progress in understanding how t
 he SAC effector\, known as the mitotic checkpoint 
 complex (MCC)\, assembles from its individual comp
 onents to inhibit its target\, the anaphase promot
 ing complex/cyclosome (APC/C). Conversely\, how mi
 crotubule attachment to kinetochores regulates the
  SAC remains incompletely understood. From a molec
 ular perspective\, answering this question implies
  investigating the mechanisms that promote targeti
 ng of the SAC proteins to unattached kinetochores\
 , and suppress it upon microtubule binding and bio
 rientation. In our recent work\, we have combined 
 biochemical reconstitutions\, structural biology/m
 odelling\, and cell biology to gain insights into 
 this fundamental biological question.  
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0
 QH) and via Zoom\, link: https://mrc-lmb-cam-ac-uk
 .zoom.us/j/96608781341?pwd=MG5QMXVmOStXcFVtalBqUlB
 Yc0tEdz09
CONTACT:Scientific Meetings Co-ordinator
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