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SUMMARY:Role of mechano-gated ion channels in epithelial tissue morphogene
 sis - Prof. Jorg Grosshans\, Philipps University Marburg\, Germany
DTSTART:20231009T133000Z
DTEND:20231009T143000Z
UID:TALK206209@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Force-gated channels enable sensation of touch and sound by tr
 ansducing mechanical stimuli into ion influx and an action potential. Howe
 ver\, their function remains unclear in mechano-sensation and force genera
 tion during epithelial morphogenesis. Here\, we have analyzed multiple mec
 hano-gated ion channels for a function in tissue morphogenesis\, including
  Tmc. We found that Tmc channels control intracellular Ca2+ in epithelial 
 wounding and synchronize periodic cell contractions in a force-generating 
 embryonic epithelium. As predicted by a data-driven model for cell synchro
 nization\, Tmc- dependent synchronization establishes isotropic force bala
 nce and cell morphology by mediating the emergence of a ring-like array of
  synchronously contracting cells shielding the tissue from external stress
 es. Thus\, Tmc transduces forces into Ca2+ signals that synchronize and pa
 ttern cell behavior. Our results suggest that the evolution of mechano-tra
 nsduction in metazoans has tailored force-gated ion channels dually for de
 tecting environmental and morphogenetic force.
LOCATION:Online
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