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SUMMARY:Condensates: role in epigenetic inheritance and a simple experimen
 tal model system - Helmut Schiessel (Technische Universität Dresden)
DTSTART:20231013T133000Z
DTEND:20231013T141000Z
UID:TALK205243@talks.cam.ac.uk
DESCRIPTION:Biomolecular condensates allow cells to overcome various physi
 cal challenges in a relatively simple manner. As an example\, we propose t
 hat cells use specialized condensates to reconstruct epigenetic informatio
 n that is lost during replication. Chromatin itself plays an important rol
 e in the formation of these condensates (see previous talk on polymer-assi
 sted condensation). Missing epigenetic tags are then placed back on the nu
 cleosomes via special enzymes located inside the condensates. I present so
 me unpublished computer simulations that provide a proof of concept. In th
 e second part of my talk\, I switch gears and present some ongoing experim
 ents with a low-cost experimental model system based on PEG-dextran soluti
 ons\, in which the resulting physical droplet properties can be controlled
  by adding DNA and spermidine.
LOCATION:Seminar Room 1\, Newton Institute
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