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SUMMARY:Diastereoselective self-assembly of low-symmetry metal-organic cag
 es - Dr Jamie Lewis\, University of Birmingham
DTSTART:20230920T130000Z
DTEND:20230920T140000Z
UID:TALK204532@talks.cam.ac.uk
CONTACT:Sharon Connor
DESCRIPTION:Metal-organic cages (MOCs) are functional host architectures o
 f intense interest for applications in catalysis\, sensing and stabilisati
 on of reactive species\, amongst others. The vast majority of MOCs reporte
 d employ symmetrical ligands to facilitate the self-assembly process\, as 
 lower symmetry ligands have the potential to form mixtures of isomeric pro
 ducts. Control of this self-assembly process\, however\, would allow acces
 s to more structurally sophisticated architectures\, with implications for
  advanced functionality and guest-binding selectivity.\n\nWe have been int
 erested in developing design strategies to bias the formation of particula
 r MOC isomers from unsymmetrical ligand scaffolds. Towards this\, we have 
 successfully used covalent tethering as well as geometric and coordination
 -sphere design parameters to induce diastereoselective assembly of palladi
 um(II)-based MOCs from ligands lacking bilateral symmetry. We have also be
 gun to develop high-throughput computational methodologies to aid in the d
 esign of such systems\, reducing costly trial-and-error synthetic discover
 y. Ongoing work is focused on extending our toolbox of design principles f
 or accessing structurally complex\, low-symmetry MOCs\, and exploiting the
  observed correlation between experimental and computational results to al
 low in silico analysis for effective computational forecasting to aid in t
 he design of future systems.\n
LOCATION:Dept. of Chemistry\, Pfizer Lecture Theater
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