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SUMMARY:Mathematical modelling of tubular structures for applications in n
 anotechnology - Farzad Fatehi Chenar (University of York)
DTSTART:20230824T083000Z
DTEND:20230824T090000Z
UID:TALK204025@talks.cam.ac.uk
DESCRIPTION:Protein cages\, convex polyhedral protein containers self-asse
 mbled from multiple copies of identical protein subunits\, are pillars of 
 nanotechnology. They include naturally occurring virus capsids (virus-like
  particles) and artificially designed protein cages\, which exhibit a plet
 hora of spherical and tubular morphologies. In this talk I will present a&
 nbsp\;mathematical analysis of tubular particles. It has been observed tha
 t the self-assembly of variants of the Aquifex aeolicus Lumazine Synthase 
 (AaLS) pentamers leads into two geometrically distinct tubular structures.
  I will present the mathematical principles of tubular architectures that 
 have recently been observed experimentally. This allows me to classify all
  geometrically viable options and illustrates why only two types of tubes 
 are biologically feasible.\nFarzad Fatehi1\, Lukasz Koziej2\, Yusuke Azuma
 2\, Reidun Twarock2\n1University of York\, 2Jagiellonian University
LOCATION:External
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