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SUMMARY:Active flows in three-dimensional cell aggregates - Guillame Salbr
 eux  (University of Geneva)
DTSTART:20230907T084000Z
DTEND:20230907T092000Z
UID:TALK203866@talks.cam.ac.uk
DESCRIPTION:Biological tissues self-organise thanks to patterning processe
 s coupled to cellular mechanical interactions\, which play a fundamental r
 ole in driving coordinated cell movements. &nbsp\;Here I will discuss how 
 polarity-oriented active mechanical forces drive collective cell motion in
  three dimensions. I will introduce the framework of &laquo\; interacting 
 active surfaces &raquo\;\, which describe cell aggregates as mechanically 
 coupled flowing active surfaces. I will discuss the three-dimensional rota
 tional motion of cell doublets\, which arise from polarised distribution o
 f myosins in the actomyosin cortex of the doublet cells. I will discuss ho
 w the shape of the doublet interface can be understood from an analysis of
  the group of symmetry of the cell doublet and application of the Curie pr
 inciple. I will then discuss how principles of polarity dynamics and polar
 ity-based mechanical interaction can act in larger three-dimensional cellu
 lar aggregates.
LOCATION:Seminar Room 1\, Newton Institute
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