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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Guided by curvature: A theoretical model of cellul
 ar shape dynamics and motility\, coupling curvatur
 e and activity - Nir Gov (Weizmann Institute of Sc
 ience)
DTSTART;TZID=Europe/London:20230905T113000
DTEND;TZID=Europe/London:20230905T120000
UID:TALK203824AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/203824
DESCRIPTION:How cells can control their shapes\, and utilize t
 hese shape changes functionally\, for example duri
 ng migration\, is an ongoing challenge in biology.
  One mechanism is by expressing curved membrane pr
 oteins\, while in addition\, cells deform their me
 mbranes by exerting cytoskeleton-based forces\, su
 ch as the recruitment of actin polymerization to t
 he membrane. Combining these two membrane deformin
 g mechanisms\, opens up the possibility for a vari
 ety of feedbacks. For example\, convex proteins (p
 rotruding outwards) enhance their aggregation when
  recruiting protrusive forces (due to actin polyme
 rization)\, and this coupling can induce strong pa
 ttern formation that spontaneously breaks the unif
 orm state. The study of how membranes deform and e
 volve when driven by this curvature-activity coupl
 ing for unrestricted (larg! e) deformations\, has 
 only just began. We have found that this system ca
 n explain the lamellipodia-driven spreading of adh
 ering cells\, and that it contains the minimal ing
 redients to exhibit spontaneous motility. We prese
 nt results on the role of the curvature-force coup
 ling in the context of different cellular problems
 \, such as phagocytosis\, cell migration over curv
 ed surfaces\, filopodia protrusions\, macropinocyt
 osis and response of cells to shear flow. The simp
 licity of the model\, with a small number of compo
 nents\, enables us to gain deep understanding of a
  large variety of biological phenomena.
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:
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