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SUMMARY:Nonlinear Elasticity and Rheological Behavior in Dense Tissues - D
 apeng Bi (Northeastern University)
DTSTART:20230904T125000Z
DTEND:20230904T133000Z
UID:TALK203803@talks.cam.ac.uk
DESCRIPTION:Biological phenomena ranging from morphogenesis to tumor progr
 ession inherently generate shear stresses within living tissue. However\, 
 the mechanisms that facilitate the transmission of these mechanical forces
  within epithelia and enable the tissue's collective response to bulk shea
 r deformations are not fully understood. My talk aims to explore these com
 plex processes using a simplified\, cell-based computational model to unde
 rstand the behavior of confluent tissues subjected to simple shear deforma
 tion. Our study illustrates how an initially uniform\, fluid-like tissue g
 ains significant rigidity once the applied strain exceeds a critical level
 \, echoing similar patterns observed in various soft matter systems. More 
 interestingly\, when focusing on the rheological response of a tissue near
  this critical point of shear-induced rigidity\, we discover a fascinating
  interplay between internal active forces and an externally imposed shear.
  This interaction gives rise to a variety of unique rheological behaviors\
 , such as yielding\, shear thinning\, continuous shear thickening\, and di
 scontinuous shear thickening.
LOCATION:Seminar Room 1\, Newton Institute
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