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SUMMARY:Epigenetic Inheritance - Dr Nicola Iovino from Max Planck Institut
 e of Immunobiology and Epigenetics\, Freiburg
DTSTART:20240201T140000Z
DTEND:20240201T150000Z
UID:TALK202906@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:My laboratory demonstrated that parents transmit not just gene
 tic but also epigenetic information to progeny in the form of histone post
 -translational modifications. We showed that the H3K27me3 repressive histo
 ne mark is retained on post-meiotic oocytes\, and it is intergenerationall
 y transmitted from the germline to the next generation. This discovery rev
 ealed an entirely unanticipated role for germline-\ninherited histone modi
 fication in mediating gene regulation in the next generation early embryo.
  We could further show that de novo deposited histone variants and histone
  acetylation also regulate gene expression in the early embryo\, revealing
  a completely unanticipated role for histone modification-mediated gene re
 gulation at this developmental stage.\nIn the early embryo\, the nucleus i
 s also organised de novo in a complex hierarchical folding pattern\, inclu
 ding chromatin loops\, topologically associating domains (TADs)\, and comp
 artmental domains. We discovered a novel and fundamental role for HP1a in 
 chromatin reorganisation after fertilisation. We showed that HP1a i) contr
 ols the general folding of chromosome arms\, ii) controls the clustering a
 nd\ncompaction of heterochromatic pericentromeric regions\, and iii) contr
 ibutes to the formation of the B compartment.\nOur goal is to identify the
  epigenetic factors that sense environmental changes\, bookmark chromatin 
 in the parental germline\, and influence on the maternally and paternally 
 inherited epigenomes. Epigenetic inheritance can drive biological diversit
 y. Thus\, we expect our discoveries to unveil new concepts of basic biolog
 y and evolution.\n
LOCATION:Biffen Lecture theatre and Zoom
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