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SUMMARY:Reconfiguration and healing of contractile microtissues - Nikolaos
  Bouklas (Cornell University)
DTSTART:20230803T133000Z
DTEND:20230803T143000Z
UID:TALK202462@talks.cam.ac.uk
DESCRIPTION:This study presents a continuum multiphysics approach to mathe
 matically and physically describe the behavior of living systems\, capturi
 ng the interaction between cells and extracellular matrix (ECM) to simulat
 e tissue-level responses such as wound healing and tissue reconfiguration.
  As most processes in living systems involve highly nonlinear multiphysica
 l phenomena\, this study aims to provide insight into the locally-averaged
  details of these processes. To achieve this\, experimental observations a
 nd physical concepts are utilized to motivate theoretical formulations in 
 a nonlinear solid mechanics framework. This work utilizes an array of mixe
 d finite element formulations\, where special discretization techniques an
 d numerical analysis algorithms are discussed to simulate these complex sy
 stems accurately in a robust manner. The proposed models are validated thr
 ough experimental results that capture the changes in tissue construct sha
 pe and cell concentration for wounded and intact microtissues\, enabling t
 he interpretation of experimental data. One of the main points of this stu
 dy is to understand the collective response of cells during remodeling in 
 the context of cell-ECM interactions and its effect on tissue morphology. 
 This continuum multiphysics framework provides valuable insights into cell
 -ECM interactions that can be extended to development and cancer\, tissue 
 engineering\, and regenerative medicine\, and can aid in developing novel 
 regenerative therapies.
LOCATION:Seminar Room 1\, Newton Institute
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