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CATEGORIES:Beyond the Neuron - Cambridge Neuroscience theme s
 eminar series
SUMMARY:Astrocytic decline and paralysis\, rather than rea
 ctivity\, contribute to brain ageing and age-depen
 dent neurodegenerative diseases. - Professor Alexe
 i Verkhratsky\, Professor of Neurophysiology\, Uni
 versity of Manchester
DTSTART;TZID=Europe/London:20230629T163000
DTEND;TZID=Europe/London:20230629T173000
UID:TALK202309AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/202309
DESCRIPTION:Alexei Verkhratsky is an internationally recognise
 d scholar in the field of cellular neurophysiology
 \, best known for his contributions to our knowled
 ge of the physiology and pathophysiology of neurog
 lia. He was one of the first to discover the speci
 fic expression of neurotransmitter receptors in as
 trocytes and their activation in situ by physiolog
 ical stimulation. He demonstrated (with H. Kettenm
 ann) matching patterns of neuronal and glial recep
 tors\, thus providing the basis for the concept of
  active and reciprocal neuronal-glial communicatio
 ns. He demonstrated that these receptors are conne
 cted to calcium-mediated signalling cascades\, whi
 ch led to the important concept of glial calcium e
 xcitability. Subsequently he developed the concept
  of sodium ions as a specific signalling molecule 
 controlling local homeostatic responses of astrocy
 tes. These discoveries have made a major contribut
 ion to the development of a new doctrine of the fu
 ndamental role of neuroglia in brain function. Ver
 khratsky also pioneered the emerging field of neur
 ogliopathology\, having characterised astroglial a
 sthenia and paralysis as key pathogenetic steps in
  age-dependent neurodegenerative diseases. In a se
 ries of highly cited conceptual papers he outlined
  basic principles of glial physiology and pathophy
 siology\, which significantly influenced this rapi
 dly developing area of neuroscience. 
LOCATION: Jeffrey Cheah Biomedical Centre Lecture Theatre
CONTACT:Dr Stefano Pluchino
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