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CATEGORIES:Biochemistry Seminar Series - External Speakers
SUMMARY:RNA Controls DNA in the Human Cell Nucleus - Tom C
 ech\, Distinguished Professor of Biochemistry\, Un
 iversity of Colorado Boulder\, and Investigator\, 
 Howard Hughes Medical Institute
DTSTART;TZID=Europe/London:20230614T150000
DTEND;TZID=Europe/London:20230614T163000
UID:TALK202108AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/202108
DESCRIPTION:Transcription factors\, histone methyltransferases
 \, DNA methyltransferases\, CTCF\, and RNA pol II 
 – which must necessarily bind chromatin - also bin
 d RNA. In many cases\, the RNA and DNA binding sit
 es overlap enough that their binding is mutually a
 ntagonistic. We have determined the cryo-EM struct
 ure of Polycomb Repressive Complex 2 (PRC2) bound 
 to RNA\, which gives unexpected insights regarding
  the mechanism of RNA inhibition. Furthermore\, we
  find that PRC2 and other DNA- and RNA-binding pro
 teins can be directly transferred or “handed off” 
 between nucleic acid ligands without a free protei
 n intermediate. Such direct transfer may be necess
 ary for these proteins to find their cognate bindi
 ng sites in cells and may be a prerequisite for bi
 ological condensates to facilitate recruitment of 
 proteins to chromatin.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Te
 nnis Court Road
CONTACT:
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