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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Spatio-Temporal Heterogeneities in a Mechano-Chemi
 cal Model of Collective Cell Migration - Andreas B
 uttenschoen (University of Massachusetts)
DTSTART;TZID=Europe/London:20230810T160000
DTEND;TZID=Europe/London:20230810T170000
UID:TALK201451AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/201451
DESCRIPTION:Small GTPases\, such as Rac and Rho\, are well kno
 wn central regulators of cell morphology and motil
 ity\, whose dynamics also play a role in coordinat
 ing collective cell migration. Experiments have sh
 own GTPase dynamics to be affected by both chemica
 l and mechanical cues\, but also to be spatially a
 nd temporally heterogeneous. This heterogeneity is
  found both within a single cell\, and between cel
 ls in a tissue. For example\, sometimes the leader
  and follower cells display an inverted GTPase con
 figuration. While progress on understanding GTPase
  dynamics in single cells has been made\, a major 
 remaining challenge is to understand the role of G
 TPase heterogeneity in collective cell migration. 
 Motivated by recent one-dimensional experiments (e
 .g. micro-channels) we introduce a one-dimensional
  modelling framework allowing us to integrate cell
  bio-mechanics\, changes in cell size\, and detail
 ed intra-cellular signalling circuits (reaction-di
 ffusion equations). Using this framework\, we buil
 d cell migration models of both loose (mesenchymal
 ) and cohering (epithelial) tissues. We use numeri
 cal simulations\, and analysis tools\, such as loc
 al perturbation analysis\, to provide insights int
 o the regulatory mechanisms coordinating collectiv
 e cell migration. We show how feedback from mechan
 ical tension to GTPase activation lead to a variet
 y of dynamics\, resembling both normal and patholo
 gical behavior.
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:
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