BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//talks.cam.ac.uk//v3//EN
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:The role of frustration in cell-fate network dynam
 ics - Herbert Levine (Northeastern University)
DTSTART;TZID=Europe/London:20230706T140000
DTEND;TZID=Europe/London:20230706T143000
UID:TALK201079AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/201079
DESCRIPTION:Recent research into the analysis of binary networ
 ks responsible for cell fate decisions (such as th
 e epithelial-mesenchymal transition of relevance f
 or cancer metastasis) have revealed that these net
 works exhibit frustration-free states which domina
 te the basins of attraction. Consequences of this 
 fact for ODE versions of these processes include t
 he collapse of dynamics onto a very small subset o
 f relevant variables and the concomitant ability t
 o coarse-grain otherwise unmanageably large system
 s. &nbsp\;This talk will review these findings and
  also present some new speculations regarding impl
 ications of this picture for the response of these
  systems to large perturbations\, as might be rele
 vant for a better understanding of the phenomenon 
 of drug persistence.
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:
END:VEVENT
END:VCALENDAR