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SUMMARY:Towards regulatory acceptance of digital outcome measures for Park
 inson’s Disease - George Roussos (Birkbeck College London)
DTSTART:20230509T150000Z
DTEND:20230509T160000Z
UID:TALK196261@talks.cam.ac.uk
CONTACT:Cecilia Mascolo
DESCRIPTION:Parkinson’s is the second most common age-related neurodegen
 erative disease and no treatments exist that can affect its underlying cau
 se. Currently available medications can modify symptoms but do not prevent
  or delay disease progression: Levodopa\, discovered in the 1960s\, contin
 ues to be the most efficacious drug. While the number of candidate compoun
 ds for new medicines continues to expand\, over the past three decades the
  number of new licensed compounds has been sparse. A key reason for this l
 ack of progress is the paucity of objective\, sensitive\, and clinically i
 nterpretable measures that can capture meaningful aspects of the disease. 
 This situation is compounded by the considerable heterogeneity in clinical
  manifestations of Parkinson’s across patients and the highly fluctuatin
 g nature of its symptoms. Digital health technologies\, typically incorpor
 ating smartphone apps and wearable sensors\, offer the potential to enable
  the objective\, decentralised\, and frequent measurement of Parkinson’s
  signs and symptoms in natural living environments. This talk reports on r
 ecent developments and key remaining challenges towards providing conclusi
 ve evidence aligned to regulator expectations so that outcomes measures cr
 eated using such digital technologies can be adopted in drug development s
 tudies.
LOCATION:FW26\, Computer Laboratory\, William Gates Building and Online
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