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SUMMARY:Mapping stromal heterogeneity and immunosuppression in breast canc
 er - Fatima Mechta-Grigoriou
DTSTART:20231214T113000Z
DTEND:20231214T123000Z
UID:TALK195454@talks.cam.ac.uk
CONTACT:112039
DESCRIPTION:\nAbstract\nIn the last years\, we demonstrated the plasticity
  of cancer-associated fibroblasts (CAF) through reciprocal crosstalk with 
 both cancer and immune cells\, and identified distinct identities and mult
 iple roles of CAF populations in metastatic spread and immunosuppression (
 Pelon\, Nat Commun\, 2020\; Bonneau Br. Cancer Res.\, 2020\; Magagna\, Can
 cers\, 2021\; Mieulet\, Sci. Reports\, 2021). Because of the dual (pro-met
 astatic and immunosuppressive) function of the FAP+ CAF population (called
  CAF-S1)\, we hypothesized that this population is more complex than initi
 ally thought. We performed single-cell RNA sequencing of more than 18 000 
 CAF-S1 isolated from breast cancer\, generating one of the most exhaustive
  studies of this CAF population in human cancer (Kieffer\, Cancer Discover
 y\, 2020\; Mhaidly\, Semin. Immunol.\, 2020\; Mhaidly\, Immunol Rev.\, 202
 1). We identified 8 FAP+ CAF / CAF-S1 cellular clusters and demonstrated t
 hat the immunosuppressive activity of CAF-S1 is restricted to specific clu
 sters\, which also predict immunotherapy resistance (Kieffer\, Cancer Disc
 overy\, 2020\; Peltier\, Sem. Cancer Biol.\, 2022\; Mhaidly\, Cancer Cell\
 , 2022). Finally\, we have recently evaluated the impact of chemotherapy o
 n CAF populations (Licaj\, Under Review) and defined FAP+ CAF / CAF-S1 pla
 sticity and spatial topology in breast cancer (Croizer\, Under Review). In
 terestingly\, we recently showed that these fibroblast populations can als
 o be observed in chronic fibrotic disease\, showing that our findings are 
 not restricted to cancer but can be widely extended to other pathologies (
 Cohen\, Nat Commun\, In press).\n\nRecent publications \nCohen\, Nature Co
 mmunications\, In press\nKieffer Y.\, Cancer Discovery\, 2020 May 20:CD-19
 -1384\nPelon F.\, Nature Communications\, 2020 Jan 21\;11(1):404\nBonneau 
 C.\, Breast Cancer Research\, 2020 Jul 14\;22(1):76\nGentric G.\, Cell Met
 abolism\, 2019\, 29\, 156-173\nCosta A.\, Cancer Cell\, 2018 Mar 12\;33(3)
 :463-479.e10\nGivel AM\, Nature Communications\, 2018\, Mar 13\;9(1):1056\
 n
LOCATION:CRUK CI Lecture Theatre
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