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SUMMARY:Using ‘omics to generate new insights into insulin-regulate gluc
 ose transport and insulin resistance & Don't drown your cells – consider
 ing oxygen tension in cell culture - Dr Daniel Fazakerley\; Institute of M
 etabolic Science\, Cambridge
DTSTART:20230131T133000Z
DTEND:20230131T143000Z
UID:TALK193546@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:My group are primarily interested how insulin regulates the tr
 ansport of glucose into fat and muscle tissues. This process is important 
 for lowering blood glucose after a meal\, and impaired insulin-stimulated 
 glucose uptake (or insulin resistance) is a risk factor for a number of me
 tabolic disease including type 2 diabetes. In the first part of my talk\, 
 I will discuss how we have used genomics\, proteomics and phosphoproteomic
 s analyses to shed light on insulin-stimulated glucose transport and how i
 t is dysregulated in insulin resistance.  In the second part\, I will talk
  about the importance of considering peri-cellular oxygen concentrations i
 n cell culture. Contrary to popular belief\, we have found that cell cultu
 re is not a state of artificially high oxygen tension\, but that cells can
  be hypoxic under standard culture conditions. Increasing oxygen availabil
 ity has profound effects on metabolism and the phenotypic characteristics 
 of our cells.\n\nDaniel undertook his PhD at university of Bath (2006-2010
 ) with Prof Geoff Holman working on GLUT4 in muscle and translocation resp
 onses to insulin and exercise/contraction stimuli. After this\, he was awa
 rded a Henry Wellcome Fellowship to go to Sydney to work with Prof David J
 ames\, first at the Garvan Institute of Medical Research and then Universi
 ty of Sydney. During this time Daniel continued his work on GLUT4 traffick
 ing\, but this time interrogating the causes of insulin resistance using c
 ultured cells and in vivo models\, with a focus on mitochondrial oxidant d
 riven insulin resistance. Daniel stayed in Sydney until 2019\, when he was
  awarded an MRC/UKRI CDA to start his lab at the IMS\, University of Cambr
 idge. Daniel and his group focus primarily investigate mechanisms of insul
 in-regulated glucose uptake and insulin resistance.   \n
LOCATION:Kings Hedges Room 
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