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SUMMARY:Reprogramming and Printing DNA Nanostructures - Hanadi Sleiman\, M
 cGill University
DTSTART:20230112T113000Z
DTEND:20230112T123000Z
UID:TALK192509@talks.cam.ac.uk
CONTACT:Catherine Pearson
DESCRIPTION:The DNA “alphabet” (A\, T\, G\, C) is the underlying code 
 that gives rise to the double helix structure. Developing a larger\, desig
 ner alphabet of DNA bases would enhance the applications of DNA structures
 \, but this goal requires costly and complex synthetic procedures. We will
  describe the discovery that small molecules can be added to unmodified DN
 A\, to re-program its self-assembly into new and unique structures\, beyon
 d Watson-Crick-Franklin base-pairing. This is a fundamental shift in the f
 ield\, as it expands the DNA code without complex synthesis. The resulting
  DNA structures can be applied to gene delivery\, tissue regeneration and 
 materials science.\n\nDespite some recent advances in cost and scalability
 \, DNA nanostructures are far from becoming readily available\, commodity 
 materials. Materials made entirely of DNA may present problems of stabilit
 y and difficult cellular entry\, and they may not be ideal for all biologi
 cal applications. We will describe the use of DNA structures as transient 
 templates\, as opposed to permanent scaffolds: a programmed DNA pattern in
  the parent template can be covalently ‘printed’ onto a different mate
 rial. The approach presents the distinct advantage of recycling the DNA te
 mplate for high throughput\, scalable generation of patterned structures. 
 It introduces the fundamental notion that supramolecular information can b
 e transmitted from one material to another through a chemical process.
LOCATION:Open Plan Area\, BP Institute\, Madingley Rise CB3 0EZ
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