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SUMMARY:Intramural structure of coronary arteries and transmural distribut
 ion of coronary blood flow - Spaan\, JAE (Academic Medical Center Amsterda
 m)
DTSTART:20090723T104500Z
DTEND:20090723T110000Z
UID:TALK19153@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Coronary arteries distribute flow over the epicardium and bran
 ch into transmural arteries\, which over about 10 orders of branching node
 s connect to the capillary bed for exchange of nutrients between blood and
  tissue. Understanding of the 3-dimensional structure of the intramural va
 scular system is needed to understand local mis-balance between supply and
  demand that especially may occur at the subendocardium. This mis-balance 
 is the explanation for the observation that infarctions most often start a
 t the subendocardium. The intramural vascular structure of larger animals 
 and humans can now be studied by a novel imaging cryomicrotome (slicing at
  40 microns\, in plane pixels of cutting plane images: 4000*4000) by study
 ing the distribution of fluorescently labeled elastomer by which the arter
 ial system is filled. Flow distributions are then measured from fluorescen
 tly labeled microsphere distributions (5 colors) injected at different phy
 siological conditions with the heart still in situ. Since microsphere dist
 ribution and arterial structure are measured in the same heart\, for the f
 irst time intramural vascular structure and flow distribution can be studi
 ed concomitantly. 
LOCATION:Seminar Room 1\, Newton Institute
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