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SUMMARY:CD22 and Siglec-G:  Two inhibitory receptors on B cells with disti
 nct functions - Professor Lars Nitschke\, University of Erlangen\, Germany
DTSTART:20090617T113000Z
DTEND:20090617T123000Z
UID:TALK18324@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:Dr Nitschke is a professor of Genetics from Erlangen Universit
 y\, currently on Sabbatical in Cambridge. His lab in Erlangen is intereste
 d in B cell immunology. They are working on the process of B cell maturati
 on and are trying to understand how B cell activation and the induction of
  the humoral immune response is regulated. \n\nIn the last years they have
  been concentrating on a family of inhibitory receptors on B cells\, the S
 iglec family. These inhibitory receptors regulate B cell receptor signalli
 ng by recruitment of tyrosine phosphatases to their intracellular inhibito
 ry ITIM motifs. They also bind with their extracellular domains to sialic 
 acids on cell surface proteins\, which further modulates B cell signalling
 .\n\nB lymphocytes express CD22 and Siglec-G. Mouse models showed that CD2
 2 is a general inhibitory receptor on most B lymphocytes\, while Siglec-G 
 regulates a subpopulation of B cells\, so-called B1 cells\, which have spe
 cific functions in the immune system.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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