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SUMMARY:How tissues orchestrate growth and morphogenesis – lessons from 
 the vertebrate retina  -    Mauricio Rocha Martins (Instituto Gulbenkian 
 Ciência (IGC)\, Oeiras\, Portugal) 
DTSTART:20221017T133000Z
DTEND:20221017T143000Z
UID:TALK183131@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Most developing tissues acquire functional architecture as the
 y still undergo significant growth. How differentiating and proliferating 
 cells cooperate in crowded yet dynamic tissue environments in order to pre
 vent spatial interference remains\, however\, largely unclear. In this sem
 inar\, I will introduce how we use the developing retina of zebrafish and 
 human organoids to probe cell movements important for tissue growth and or
 ganization\, as well as their coordination in space and time. I will prese
 nt how quantitative imaging approaches revealed an unknown bidirectional m
 igration phenomenon of one of the most studied retinal neurons\, photorece
 ptors. Interestingly\, this bidirectional migration occurs at peak prolife
 ration stages and culminates in a transient relocation of the entire cell 
 population away from the proliferative zone. We performed a comprehensive 
 analysis of the molecular motors driving photoreceptor movements in differ
 ent directions\, and then exploited these mechanistic insights to determin
 e the relevance of their movements to overall tissue morphogenesis. We fou
 nd that photoreceptor movements are not directly needed for their correct 
 lamination. However\, blockage of photoreceptor migration congests the mit
 otic zone of the tissue causing intense progenitor delamination followed b
 y secondary tissue disorganization. Our findings highlight that neuronal m
 igration can play an important role in coordinating growth and morphogenes
 is by preventing spatial competition. 
LOCATION:Online
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