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SUMMARY:Contributed Talk: Unicellular and multicellular stress responses i
 n bacterial biofilms - Knut  Drescher  (Universität Basel)
DTSTART:20221012T105500Z
DTEND:20221012T111500Z
UID:TALK179363@talks.cam.ac.uk
DESCRIPTION:In nature\, bacteria primarily live in surface-attached commun
 ities termed biofilms\, in which cells are attached to each other through 
 an extracellular matrix. These biofilms represent the most abundant form o
 f biomass on our planet. In this presentation\, I will discuss emergent fu
 nctional benefits of the biofilm community lifestyle\, in the context of s
 tress responses of bacteria inside biofilms. I will first introduce new mi
 croscopy and image processing techniques that enable us to monitor all ind
 ividual cells in living biofilms. Based on these techniques\, I will then 
 show how we can distinguish stress responses that occur at the single-cell
  level from stress responses that occur at the multicellular level. For th
 e response of biofilms to antibiotics\, and the response to starvation\, I
  will discuss in detail the mechanisms of the biofilm-specific multicellul
 ar stress response. From these measurements can draw conclusions for how a
 ntibiotic tolerance emerges in biofilms\, and we provide new treatment ave
 nues for infections in which antibiotic therapy is currently not successfu
 l.
LOCATION:Seminar Room 1\, Newton Institute
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