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CATEGORIES:Babraham Seminar
SUMMARY:Towards a quantitative understanding of long-range
  transcriptional regulation - Dr Luca Giorgetti\; 
 Friedrich Miescher Institute for Biomedical Resear
 ch
DTSTART;TZID=Europe/London:20220927T133000
DTEND;TZID=Europe/London:20220927T143000
UID:TALK176483AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/176483
DESCRIPTION:In mammals\, the control of gene expression relies
  on tens of thousands of enhancer sequences that a
 re differentially active in every cell type. Enhan
 cers engage with target promoters often from large
  genomic distances and govern their spatio-tempora
 l and quantitative expression dynamics. Genetic va
 riation within these noncoding regions is a major 
 driver of evolution\, but is also causal to develo
 pmental disorders and numerous human diseases. Des
 pite their central role in gene regulation in heal
 th and disease\, however\, the principles by which
  enhancers select and control their target genes r
 emain largely unknown. What are the molecular mech
 anisms that transmit regulatory information from a
 n enhancer to a promoter?  How are they related to
  chromosome structure and physical interactions be
 tween enhancers and promoters?  Are these mechanis
 ms universal or rather depend on locus- and tissue
 -specific contexts? My group addresses these funda
 mental questions at the interface of molecular bio
 logy and biophysics using a tight interplay of exp
 erimental and theoretical approaches. In my talk\,
  I will present how using a combination of genomic
  engineering\, physical modeling and live-cell ima
 ging we recently discovered that a promoter’s tran
 scription level are a nonlinear function its conta
 ct probabilities with a cognate enhancer\, and how
  this could arise from dynamic and unstable physic
 al interactions between enhancers and promoters.\n
 \nAfter studying physics\, Luca obtained his PhD i
 n Gioacchino Natoli’s lab at the European Institut
 e of Oncology in Milan working on the molecular me
 chanisms underlying the inflammatory transcription
 al response. He then moved to Paris for a postdoc 
 with Edith Heard at the Curie Institute. There he 
 participated to the discovery and characterization
  of topologically associating domains (TADs)\, and
  described the three-dimensional conformation of t
 he inactive X chromosome. Luca has been a group le
 ader at the Friedrich Miescher Institute for Biome
 dical Research (FMI) in Basel since 2015. His grou
 p uses approaches at the interface between molecul
 ar biology and physics to understand the mechanism
 s by which chromosome structure and dynamics contr
 ol transcriptional regulation by enhancers. He is 
 the recipient of an ERC Starting Grant and an EMBO
  Young Investigator.\n\nClick here to join live - 
 https://us06web.zoom.us/j/81590547636
LOCATION:Online via zoom &amp\; Kings Hedges Room 
CONTACT:Bobbie Claxton
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