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SUMMARY:Understanding Transcriptional Cross-regulation Between Hormone Res
 ponse Pathways - Professor Mathew Lewsey\, La Trobe University
DTSTART:20220616T120000Z
DTEND:20220616T130000Z
UID:TALK171857@talks.cam.ac.uk
CONTACT:Jake Harris
DESCRIPTION:Cross-regulation between hormone response pathways is indispen
 sable for plant growth because it enables plants to respond to diverse env
 ironmental information. Hundreds of transcription factors are involved\, r
 eprogramming gene expression. Determining how these transcription factors 
 influence dynamic gene expression patterns can provide base information to
  manipulate plant-environment interactions. We have comprehensively charac
 terized transcription factor activity during plant hormone responses and g
 enerated dynamic transcriptional regulatory models to explain how signals 
 are integrated from multiple pathways. We analysed transcriptome dynamics 
 of seedlings following stimulation of six hormone pathways and identified 
 the target genes of 14 key hormone transcription factors. Using these data
  we identified hub genes targeted by multiple transcription factors and ch
 aracterized their properties in hormone transcriptional networks. We then 
 reconstructed hormone signalling pathway models by integrating dynamic gen
 e expression data with target gene information from hundreds of transcript
 ion factors and thousands of protein-protein interactions. Using these we 
 identified transcriptional regulatory properties that are common and uniqu
 e across hormones. We also identified a group of kinases that may act as c
 ore cross-regulatory hubs between hormone signalling pathways.\n\nDue to h
 aving to go online\, we are restricting the talks to University of Cambrid
 ge and alumni to keep them as informal as possible.\n\nContact reception@p
 lantsci.cam.ac.uk for a Zoom link prior to a talk.
LOCATION:Online / Plant Sciences LLT for Department members only
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