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CATEGORIES:Plant Sciences Departmental Seminars
SUMMARY:Understanding Transcriptional Cross-regulation Bet
 ween Hormone Response Pathways - Professor Mathew 
 Lewsey\, La Trobe University
DTSTART;TZID=Europe/London:20220616T130000
DTEND;TZID=Europe/London:20220616T140000
UID:TALK171857AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/171857
DESCRIPTION:Cross-regulation between hormone response pathways
  is indispensable for plant growth because it enab
 les plants to respond to diverse environmental inf
 ormation. Hundreds of transcription factors are in
 volved\, reprogramming gene expression. Determinin
 g how these transcription factors influence dynami
 c gene expression patterns can provide base inform
 ation to manipulate plant-environment interactions
 . We have comprehensively characterized transcript
 ion factor activity during plant hormone responses
  and generated dynamic transcriptional regulatory 
 models to explain how signals are integrated from 
 multiple pathways. We analysed transcriptome dynam
 ics of seedlings following stimulation of six horm
 one pathways and identified the target genes of 14
  key hormone transcription factors. Using these da
 ta we identified hub genes targeted by multiple tr
 anscription factors and characterized their proper
 ties in hormone transcriptional networks. We then 
 reconstructed hormone signalling pathway models by
  integrating dynamic gene expression data with tar
 get gene information from hundreds of transcriptio
 n factors and thousands of protein-protein interac
 tions. Using these we identified transcriptional r
 egulatory properties that are common and unique ac
 ross hormones. We also identified a group of kinas
 es that may act as core cross-regulatory hubs betw
 een hormone signalling pathways.\n\nDue to having 
 to go online\, we are restricting the talks to Uni
 versity of Cambridge and alumni to keep them as in
 formal as possible.\n\nContact reception@plantsci.
 cam.ac.uk for a Zoom link prior to a talk.
LOCATION:Online / Plant Sciences LLT for Department members
  only
CONTACT:Jake Harris
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