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SUMMARY:Mechanically-instructive Scaffolds to Steer Tissue Regeneration:  
 Merging Mechaniobiology with Biofabrication - Prof Lorenzo Moroni\, MERLN 
 Institute for Technology-Inspired Regenerative Medicine\, Complex Tissue R
 egeneration department
DTSTART:20220311T140000Z
DTEND:20220311T150000Z
UID:TALK167888@talks.cam.ac.uk
CONTACT:Sara Seddon
DESCRIPTION:Organs are complex systems\, comprised of different tissues\, 
 proteins\, and cells\, which communicate to orchestrate a myriad of functi
 ons in our bodies. Technologies are needed to replicate these structures t
 owards the development of new therapies for tissue and organ repair\, as w
 ell as for 3D in vitro models to better understand the morphogenetic biolo
 gical processes that drive organogenesis. To construct tissues and organs\
 , biofabrication strategies are being developed to impart spatiotemporal c
 ontrol over cell-cell and cell-extracellular matrix communication\, often 
 through control over cell and material deposition and placement. To achiev
 e these targets\, the spatiotemporal control over biological signals at th
 e interface between cells and materials is often aimed for. Alternatively\
 , biological activity can be triggered through the control of mechanical c
 ues\, harnessing more fundamental know-how in mechanobiology that could be
  combined with biofabrication strategies. Here\, I present some of our mos
 t recent advancements in merging mechanobiology with biofabrication that e
 nabled the control of cell activity\, moving towards enhanced tissue regen
 eration as well as the possibility to create more complex 3D in vitro mode
 ls to study biological processes.
LOCATION:CUED LR5
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