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SUMMARY:Wnt signalling in the gill arches of the little skate during devel
 opment - Jenaid Rees\, Department of Zoology\, University of Cambridge
DTSTART:20220303T130000Z
DTEND:20220303T140000Z
UID:TALK166510@talks.cam.ac.uk
CONTACT:Anna Belcher
DESCRIPTION:Pharyngeal arches are an integral feature of the embryonic ver
 tebrate head\, generating much of the craniofacial skeleton. In this talk 
 I will give a broad introduction to vertebrate pharyngeal and gill arch de
 velopment and outline my recent findings on the role of Wnt signalling in 
 the gill arches of the little skate. The gill arch skeleton of cartilagino
 us fishes (sharks\, skates\, rays and holocephalans) exhibit clear anterio
 r–posterior polarity\, with a series of appendages (branchial rays) form
 ing in the gill arch posterior. Branchial rays derive from a posterior dom
 ain of gill arch mesenchyme\, which is responsive to Shh signalling from a
  distal signalling centre called the gill arch epithelial ridge (GAER) (Gi
 llis and Hall\, 2016). However\, how the branchial rays are specified excl
 usively within the posterior gill arch is not known. Using RNAseq\, we dis
 cover that several Wnt genes are expressed adjacent to the GAER\, and that
  these Wnt signals are transduced largely in the anterior gill arch. Final
 ly\, we show that loss of Wnt signalling results in the formation of ectop
 ic anterior branchial rays. Our findings demonstrate that Wnt signalling r
 estricts cartilage formation to the posterior gill arch\, highlighting the
  importance of these signalling interactions for cell fate determination.
LOCATION:King Richard Room\, Darwin College
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