BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//talks.cam.ac.uk//v3//EN
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
CATEGORIES:Kelvin Club - The Scientific Society of Peterhouse
 \, Cambridge
SUMMARY:The Awakening of the Genome: How Embryonic Transcr
 iptional Programs are Initiated - Dr. Jasmin Stowe
 rs\, Babraham Institute 
DTSTART;TZID=Europe/London:20211109T203000
DTEND;TZID=Europe/London:20211109T220000
UID:TALK163504AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/163504
DESCRIPTION:ABSTRACT\nThe human body arises from only a single
  cell which harbours the entire genetic informatio
 n and developmental potential to give rise to a fu
 lly grown organism. This totipotent cell\, the zyg
 ote\, undergoes extensive cellular changes during 
 the first days of early embryonic development. The
  ‘Awakening of the Genome’ of the zygote is one of
  the key processes of mammalian embryogenesis\, an
 d it comprises of the structural reorganisation of
  our genetic code (the genome)\, its modification 
 (the epigenome) and its expression (the transcript
 ome). Zygotic genome activation (ZGA) in the 8-cel
 l human embryo represents the first major wave of 
 transcription which initiates protein production a
 nd creates all essential building blocks of the de
 veloping embryo. Failure to initiate ZGA accuratel
 y is fatal for the embryo. Despite its major impor
 tance for human reproduction and health\, analysin
 g the totipotent human zygote molecularly and how 
 it activates its genome\, is ethically and technic
 ally problematic. Here\, we report the finding of 
 a novel in vitro cell type\, that can be used to s
 tudy the process of embryonic genome activation in
  stem cells in cell culture. These human ‘8-cell l
 ike cells’ resemble the totipotent human 8-cell em
 bryo at the time of ZGA – transcriptionally\, epig
 enetically and phenotypically. These 8-cell like c
 ells represent a new model system that allows us\,
  for the first time\, to analyse and manipulate th
 e molecular processes of human genome activation i
 n a controllable and non-invasive way in vitro. Th
 is will enhance our understanding of one of the ea
 rliest events in human development – ‘The Awakenin
 g of the Genome’.\n\nCOVID-19 Policy\nWe kindly as
 k attendees to test negative for COVID-19 by later
 al flow the day of the event and to not attend the
  event if they have any symptoms of COVID-19. In a
 ddition\, we strongly encourage attendees to have 
 completed their full course of COVID-19 vaccines p
 rior to the event. Please wear a face covering whi
 lst not eating or drinking.\n\nThis event also wil
 l be livestreamed over Zoom.  If you would like to
  watch the livestream please register here for the
  joining details: https://docs.google.com/forms/d/
 e/1FAIpQLSf046axP5uJKdZLgkAZdgK6UetIe52MAHS16UqLiR
 RD5yojRQ/viewform?fbclid=IwAR2oijquiLvSNMWc0fM2DZO
 iIRUzVisM2pGSCbduj0N-T0pqDVPeTu2lN3g
LOCATION:The Theatre\, Peterhouse (with Zoom livestream)
CONTACT:Amanda Buckingham
END:VEVENT
END:VCALENDAR