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SUMMARY:Development Of A Multiscale Chromatin Coarse-Grained Model - Charl
 es Phillips\, University of Cambridge
DTSTART:20211117T150000Z
DTEND:20211117T153000Z
UID:TALK162427@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:In eukaryotic cells DNA is organised in the form of nucleosome
 s. An array of nucleosomes connected by linker DNA is known as chromatin. 
 Chromatin is organised across functionally different domains spanning Kb t
 o Mb scales. In this study we investigate chromatin composition and organi
 sation in vitro and in vivo and highlight some results of the intrinsic or
 ganisation of chromatin as a function of nucleosome repeat length and how 
 these results relate to experimental studies on chromatin liquid-liquid ph
 ase separation. We also study the effect of the H1 linker histone on our c
 hromatin model and highlight that it increases chromatin compaction by act
 ing as a liquid like glue for chromatin.
LOCATION:Zoom and Dept of Chemistry\, Wolfson Lecture Theatre
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