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CATEGORIES:Cambridge Neuroscience Interdisciplinary Seminars
SUMMARY:Regenerative Neuroimmunology - a stem cell perspec
 tive - Professor Stefano Pluchino\, Clinical Neuro
 sciences
DTSTART;TZID=Europe/London:20210601T160000
DTEND;TZID=Europe/London:20210601T170000
UID:TALK156982AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/156982
DESCRIPTION:Theme: *Beyond the Neuron: glia\, vascular and imm
 une cells*\n\nThere are currently no approved ther
 apies to slow down the accumulation of neurologica
 l disability that occurs independently of relapses
  in multiple sclerosis (MS). International agencie
 s are engaging to expedite the development of nove
 l strategies capable of modifying disease progress
 ion\, abrogating persistent CNS inflammation\, and
  support degenerating axons in people with progres
 sive MS. \nUnderstanding why regeneration fails in
  the progressive MS brain and developing new regen
 erative approaches is a key priority for the Pluch
 ino Lab.\nIn particular\, we aim to elucidate how 
 the immune system\, in particular its cells called
  myeloid cells\, affects brain structure and funct
 ion under normal healthy conditions and in disease
 .\nOur objective is to find how myeloid cells comm
 unicate with the central nervous system and affect
  tissue healing and functional recovery by stimula
 ting mechanisms of brain plasticity mechanisms suc
 h as the generation of new nerve cells and the red
 uction of scar formation. \nApplying combination o
 f state-of-the-art omic technologies\, and molecul
 ar approaches to study murine and human disease mo
 dels of inflammation and neurodegeneration\, we ai
 m to develop experimental molecular medicines\, in
 cluding those with stem cells and gene therapy vec
 tors\, which slow down the accumulation of irrever
 sible disabilities and improve functional recovery
  after progressive multiple sclerosis\, stroke and
  traumatic injuries.\nBy understanding the mechani
 sms of intercellular (neuro-immune) signalling\, d
 iseases of the brain and spinal cord may be treate
 d more effectively\, and significant neuroprotecti
 on may be achieved with new tailored molecular the
 rapeutics.\n\nStefano received his MD and PhD degr
 ees at the University of Siena\, Italy\, with addi
 tional training at Cambridge University\, UK. He i
 s currently University Reader in Regenerative Neur
 oimmunology (2016) and Honorary Consultant in Neur
 ology\, within the Department of Clinical Neurosci
 ences at Cambridge University.\nHe has a strong in
 terest in Regenerative Neuroimmunology\, and his r
 esearch over the last 20 years has recalibrated th
 e classical view that cellular grafts only functio
 n through structural cell replacement and opened u
 p a new therapeutic avenue by which to use exogeno
 usly delivered stem cells\, or even stem cell-deri
 ved acellular therapies that include extracellular
  vesicles and exosomes. \nThe Pluchino team studie
 s whether the accumulation of neurological disabil
 ity observed in patients with chronic inflammatory
  neurological conditions can be slowed down using 
 next generation molecular therapies. The overarchi
 ng aim is to understand the basic mechanisms that 
 allow exogenously delivered stem cells\, gene ther
 apy vectors and/or exosomes to create an environme
 nt that preserves damaged axons or prevents neuron
 s from dying. Such mechanisms may be harnessed and
  used to modulate disease states in an effort to r
 epair and/or regenerate critical components of the
  nervous system. \nHe is the recipient of numerous
  national and international awards\, among which t
 he Italian Multiple Sclerosis Foundation (FISM) Ri
 ta Levi-Montalcini prize for outstanding research 
 in MS (2007)\, the 2009 Italian Ministry of Health
  Young Investigator Award and the 2010 European Re
 search Council (ERC) Starting Independent Award. H
 is laboratory research on Regenerative Neuroimmuno
 logy is documented in >220 publications and have r
 eceived >12.500 citations (ISI-WOK)\, with a Hirsc
 h Factor of 50.\n\nRegister in advance for this me
 eting:\nhttps://us02web.zoom.us/meeting/register/t
 ZYkde2vpzkqHd3781cn6IVUGzMQA106vt4U \n\nAfter regi
 stering\, you will receive a confirmation email co
 ntaining information about joining the meeting.
LOCATION:Register on Zoom - link in abstract
CONTACT:Dr Dervila Glynn
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